Meta-regression analysis showed that the difference between angiotensin-converting enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) compared with placebo was due to a higher placebo event rate in the ACE inhibitor trials for the outcome of all-cause mortality, cardiovascular death, and myocardial infarction.
12 Jan 2016
A new statement from the American Heart Association recommends that in patients taking amlodipine combined with simvastatin or lovastatin, the dosage of either statin should not exceed 20 mg/d, and for patients in whom statin-fibrate therapy is indicated, fenofibrate or fenofibric acid is preferred because of a lower rate of drug-drug interactions.
25 Oct 2016
By making the most of team members and technology, internists can free up valuable physician-patient interaction time to most effectively apply cancer screening guidelines.
1 Oct 2019
Recent efforts have pushed institutions to reconsider the use of race not just in estimating kidney function, but in a variety of algorithms and scores.
1 May 2021
A 47-year-old man is evaluated during a routine examination. He has no symptoms. Medical history is significant for a bicuspid aortic valve. He is not taking any medications. Following a physical exam, cardiac exam, and echocardiogram, what is the most appropriate management?
18 Oct 2016
This column reviews details on recent recalls, warnings, and approvals.
1 Nov 2020
Internists can have the greatest impact by continuing to be the first point of contact, treating mild to moderate depression, and explaining what may be available if first-line options fall short.
1 Sep 2019
A 68-year-old woman is evaluated for a 3-month history of gradually progressive abdominal distention. Her medical history is notable for a 20-year history of obesity, type 2 diabetes mellitus, hyperlipidemia, and hypertension. She also has had a 10-year history of elevation of serum aminotransferase levels, which was attributed to nonalcoholic fatty liver disease. She does not consume alcohol. Her medications are metformin, lisinopril, low-dose aspirin, and simvastatin. Following a physical exam and lab studies, what is the most appropriate next step in management?
8 Nov 2016
Patients receiving early beta-blockers had a 30-day mortality rate of 2.3%, compared with 8.6% in those who did not, the study found.
27 Sep 2016
A study reinforces the usefulness of ACC/AHA CVD Pooled Cohort risk equations and the importance of efforts to implement the current guidelines to prevent atherosclerotic cardiovascular disease in African Americans.
1 Mar 2016