Crossed Words: Holiday surprise
By Justin Vader, MD, ACP Resident/Fellow Member
Answers to clues are placed horizontally in rows to reveal an answer written vertically. Unlike the familiar acrostic puzzle format, the final answer can be in any column.
1) The effect of Mustard on mixed-up blood in the heart
2) Pretty primitive as reflexes go
3) Brain nucleus with a bend toward appetite
4) Selective, akinetic—we can’t say
5) Scintillating feature of migraine
6) Diagnosis takes time or Kveim
7) Can be a real pain in the butt ... and thigh
8) Baker’s dozen pounds, different metric
Find in the vertical columns: Christmas never had enough of this. The puzzle grid is here.
Answer: Factor IX
The answer grid is here. Deficiency of factor IX causes Christmas disease, or hemophilia B. The original mutation was identified in 1952 by sequencing the DNA of a young boy named Stephen Christmas, who was found to be lacking this factor. Recombinant factor IX is used to treat Christmas disease, and a formulation is commercially available. (Source)
Holiday bonus clue: Find another holiday-related item (minus an “E”) in the vertical columns.
Photo by iStock
Internist Archives Quick Links
Reviews of the World's Top Medical Journals—FREE to ACP Members!
ACP JournalWiseSM is mobile optimized with optional email alerts! Get access to reviews from over 120 of the world’s top medical journals alerting you to the highest quality, most clinically relevant new articles based on your preferred areas of specialty. ACP Members register your FREE account now!
New CME Option: Internal Medicine 2014 Recordings
New CME Package
Includes 75 of the most popular sessions in internal medicine and the subspecialties. Stream the sessions, answer brief quizzes and earn CME credit. See details.